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Glutamate receptor 4

Summary

UniProt ID: Q9Z2W8
Gene Symbol: Glur4 Gria4
Gene ID: 14802
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0007863

GlyConnect

Glutamate receptor 4

GlyGen

Q9Z2W8

PubChem

Q9Z2W8

Re-Glyco

Q9Z2W8

Annotation

Keyword: Cell membrane Cell projection Disulfide bond Glycoprotein Ligand-gated ion channel Palmitate Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
chemical synaptic transmission	ISO	GO_REF
negative regulation of smooth muscle cell apoptotic process	ISO	GO_REF
synaptic transmission, glutamatergic	IBA	GO_REF
modulation of chemical synaptic transmission	ISO	GO_REF
modulation of chemical synaptic transmission	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

regulation of smooth muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, glutamatergic

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of smooth muscle cell apoptotic process

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	IEA	GO_REF
postsynaptic density	ISO	GO_REF
dendrite	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

presynapse [inference]

terminal bouton

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
glutamate-gated receptor activity	ISS	GO_REF
glutamate-gated receptor activity	ISO	GO_REF
AMPA glutamate receptor activity	ISS	GO_REF
AMPA glutamate receptor activity	ISO	GO_REF GO_REF
AMPA glutamate receptor activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

binding [inference]

protein binding [inference]

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

AMPA glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
52	N-linked (GlcNAc...) asparagine			UniProt GlyGen
56	N-linked (GlcNAc...) asparagine		G75418YA	UniProt GlyGen
258	N-linked (GlcNAc...) asparagine	30899004	G90445GN G14260UH G64527OM G39188ZX	GlycoProtDB UniProt GlyGen GlyConnect
371	N-linked (GlcNAc...) asparagine	30899004	G83646BJ G70101JE G64527OM G39188ZX G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
407	N-linked (GlcNAc...) asparagine	30899004	G64527OM G02815KT	GlycoProtDB UniProt GlyGen GlyConnect
414	N-linked (GlcNAc...) asparagine		G26436YP	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of AMPA receptors	Mus musculus
Synaptic adhesion-like molecules	Mus musculus
Trafficking of AMPA receptors	Mus musculus
Trafficking of GluR2-containing AMPA receptors	Mus musculus
Unblocking of NMDA receptors, glutamate binding and activation	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements