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MIRAGE

Regenerating islet-derived protein 3-alpha

Summary

Lectin Name Aliases

Islet of Langerhans regenerating protein 3
Lithostathine 3
Pancreatitis-associated protein 2
REG 3
REG-3-alpha
Reg III-alpha
RegIII
Regenerating islet-derived protein III-alpha

Organism

Rattus norvegicus (Norway rat)

External Links

UniProt: P35231

Annotation

Keyword: Acute phase Antimicrobial Disulfide bond Inflammatory response Lectin Metal-binding Reference proteome Secreted Signal Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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Last »
GO Term	Evidence Code	Reference
acute-phase response
positive regulation of cell population proliferation	IBA	GO_REF
positive regulation of keratinocyte proliferation	ISS	GO_REF
positive regulation of keratinocyte proliferation	ISO	GO_REF
response to peptide hormone	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to hormone [inference]

response to peptide hormone

response to nitrogen compound [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide hormone

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of keratinocyte differentiation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

positive regulation of wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

positive regulation of keratinocyte proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

negative regulation of keratinocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of keratinocyte proliferation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of keratinocyte differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation [inference]

negative regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

negative regulation of keratinocyte differentiation

Displaying 1 entry
GO Term	Evidence Code	Reference
obsolete extracellular space

GO Hierarchy

cellular component

Displaying **all 4** entries
GO Term	Evidence Code	Reference
signaling receptor activity
peptidoglycan binding
metal ion binding
oligosaccharide binding

GO Hierarchy

molecular function

binding [inference]

carbohydrate binding [inference]

oligosaccharide binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Pathway

Displaying 1 entry
Pathway Name	Organism
Antimicrobial peptides	Rattus norvegicus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026