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Hexokinase-1

Summary

Lectin Name Aliases

NtHxK1

Organism

Nicotiana tabacum (common tobacco)

External Links

UniProt: Q9SEK2

Annotation

Keyword: ATP-binding Chloroplast Glycolysis Kinase Plastid outer membrane Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	Reference
intracellular glucose homeostasis	IEA	GO_REF GO_REF
glucose metabolic process	IBA	GO_REF
glucose metabolic process	IEA	GO_REF
glycolytic process	IBA	GO_REF
glycolytic process	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

glycolytic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nicotinamide nucleotide metabolic process [inference]

glycolytic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nicotinamide nucleotide metabolic process [inference]

glycolytic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

glucose 6-phosphate metabolic process

catabolic process [inference]

carbohydrate catabolic process [inference]

glycolytic process

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

glycolytic process

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

carbohydrate catabolic process [inference]

glycolytic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nicotinamide nucleotide metabolic process [inference]

glycolytic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process [inference]

glycolytic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nicotinamide nucleotide metabolic process [inference]

glycolytic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine nucleotide catabolic process [inference]

glycolytic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

glycolytic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

glycolytic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

ATP metabolic process [inference]

glycolytic process

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glucose 6-phosphate metabolic process

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis

Displaying **all 4** entries
GO Term	Evidence Code	Reference
mitochondrion	IEA	GO_REF GO_REF
cytosol	IBA	GO_REF
cytosol	IEA	GO_REF
chloroplast outer membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

plastid outer membrane [inference]

chloroplast outer membrane

organelle membrane [inference]

plastid membrane [inference]

plastid outer membrane [inference]

chloroplast outer membrane

chloroplast membrane [inference]

chloroplast outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

plastid outer membrane [inference]

chloroplast outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
glucokinase activity	ISS	GO_REF
glucokinase activity	IEA	GO_REF GO_REF GO_REF
ATP binding	IEA	GO_REF
D-glucose binding	IEA	GO_REF
fructokinase activity	ISS	GO_REF