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Recognition and association of DNA glycosylase with site containing an affected purine

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-110330

PubChem

R-HSA-110330

Description

The recognition and removal of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the backbone of the affected DNA strand at the site of damage. This compression is thought to result in an outward rotation of the damaged residue into a "pocket" of the enzyme that recognizes and cleaves the altered base from the backbone (Slupphaug et al. 1996, Parikh et al. 1998).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 23 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
P04908	Histone H2A type 1-B/E	H2AC4; H2AC8 H2AFA H2AFM HIST1H2AB HIST1H2AE	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P16104	Histone H2AX	H2AFX H2AX	view
P23527	Histone H2B type 1-O	H2BC17 H2BFH H2BFN HIST1H2BO	view
P29372	DNA-3-methyladenine glycosylase	AAG ANPG MID1 MPG	view
P33778	Histone H2B type 1-B	H2BC3 H2BFF HIST1H2BB	view
P57053	Histone H2B type F-S	H2BC12L H2BFS H2BS1	view
P58876	Histone H2B type 1-D	H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 H2BC5 H2BFA H2BFB H2BFG H2BFH H2BFK H2BFL HIRIP2 HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI	view
P62805	Histone H4	H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4	view

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