GlyCosmos Portal

Submissions

Resolution of AP sites via the single-nucleotide replacement pathway

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-110381

PubChem

R-HSA-110381

Description

The single nucleotide replacement pathway of base excision repair appears to facilitate the repair of most damaged bases. Following DNA glycosylase mediated cleavage of the damaged base, the endonuclease APEX1 is recruited to the site of damage where it cleaves the 5' side of the abasic (AP) deoxyribose residue. DNA polymerase beta (POLB) then cleaves the 3' side of the AP sugar phosphate, thus excising the AP residue. APEX1 is subsequently released, the XRCC1:LIG3 complex is recruited, and POLB mediates the synthesis of the replacement residue. Following LIG3 mediated ligation of the replaced residue, the XRCC1:LIG3 complex dissociates from DNA (Lindahl and Wood, 1999). An alternative BER pathway is employed when the structure of the terminal sugar phosphate is such that it cannot be cleaved by the AP lyase activity of POLB.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P18887	DNA repair protein XRCC1	XRCC1	view
P49916	DNA ligase 3	LIG3	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.