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Apoptotic cleavage of cellular proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-111465

PubChem

R-HSA-111465

Description

Apoptotic cell death is achieved by the caspase-mediated cleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adducin, HIP-55, and desmoglein involved in cell adhesion and maintenance of the cytoskeletal architecture. Cleavage of proteins such as APC and CIAP1 can further stimulate apoptosis by produce proapoptotic proteins (reviewed in Fischer et al., 2003. See also Wee et al., 2006 and the CASVM Caspase Substrates Database: http://www.casbase.org/casvm/squery/index.html ).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P25054	Adenomatous polyposis coli protein	APC DP2.5	view
P55210	Caspase-7	CASP7 MCH3	view
P55212	Caspase-6	CASP6 MCH2	view
Q01826	DNA-binding protein SATB1	SATB1	view
Q04759	Protein kinase C theta type	PRKCQ PRKCT	view
Q05397	Focal adhesion kinase 1	FAK FAK1 PTK2	view
Q13464	Rho-associated protein kinase 1	ROCK1	view
Q13490	Baculoviral IAP repeat-containing protein 2	API1 BIRC2 MIHB RNF48	view
Q9HAW4	Claspin	CLSPN	view
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	ACIN1 ACINUS KIAA0670	view

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