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Activation of NF-kappaB in B cells

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1169091

PubChem

R-HSA-1169091

Description

DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007) which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it (Wang et al. 2001). The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999), resulting in the degradation of IkB (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription (Baeuerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 30 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB IKKB	view
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	CHUK IKKA TCF16	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O43318	Mitogen-activated protein kinase kinase kinase 7	MAP3K7 TAK1	view
P17980	26S proteasome regulatory subunit 6A	PSMC3 TBP1	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
P20618	Proteasome subunit beta type-1	PSC5 PSMB1	view

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