TWIK related potassium channel (TREK)

Summary
Organism
Homo sapiens (human)
Reactome
R-HSA-1299503
PubChem
R-HSA-1299503
Description
  • TREK1 and TREK 2 are activated by physiochemical changes like stretch, convex deformation of the plasma membrane, depolarization, heat and intracellular acidosis. Polyunsaturated fatty acids (PUFA) including arachidonic acid open TREK channels.
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Displaying all 3 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O95069 Potassium channel subfamily K member 2
  • KCNK2
  • TREK
  • TREK1
view
P57789 Potassium channel subfamily K member 10
  • KCNK10
  • TREK2
view
Q9NYG8 Potassium channel subfamily K member 4
  • KCNK4
  • TRAAK
view

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026