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Acrosome Reaction and Sperm:Oocyte Membrane Binding

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1300645

PubChem

R-HSA-1300645

Description

The acrosome reaction is stimulated by zona pellucida binding and subsequent downstream events, including Ca2+ influx. Proacrosin cleavage is the hallmark event of the acrosome reaction. After the acrosome reactome the sperm has passed through the cumulus cells and the zona pellucida. The membrane of the sperm head and the membrane of the oocyte are drawn together through the interaction of the sperm-bound protein Izumo and the ooctye CD9 membrane protein.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P10323	Acrosin [Cleaved into: Acrosin light chain; Acrosin heavy chain]	ACR ACRS	view
P21926	CD9 antigen	CD9 GIG2 MIC3 TSPAN29	view
Q1ZYL8	Izumo sperm-egg fusion protein 4	C19orf36 IZUMO4 UNQ831/PRO1758	view
Q5VZ72	Izumo sperm-egg fusion protein 3	C9orf134 IZUMO3	view
Q6UXV1	Izumo sperm-egg fusion protein 2	C19orf41 IZUMO2 SCRL UNQ6978/PRO21961	view
Q8IYV9	Izumo sperm-egg fusion protein 1	IZUMO1	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_003257	P10323	Acrosin	view

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