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Synthesis of PA

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1483166

PubChem

R-HSA-1483166

Description

In the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT). In addition to this, PA is also formed when phosphatidylcholine (PC) is hydrolyzed by phospholipases D1 and D2 (PLD1 and 2). PA is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by acyltransferases (Ghomashchi et al. 2010, Singer et al. 2002, Prasad et al. 2011, Shindou & Shimizu 2009, Cao et al. 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 19 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15228	Dihydroxyacetone phosphate acyltransferase	DAPAT DHAPAT GNPAT	view
O15496	Group 10 secretory phospholipase A2	PLA2G10	view
P09923	Intestinal-type alkaline phosphatase	ALPI	view
P14555	Phospholipase A2, membrane associated	PLA2B PLA2G2A PLA2L RASF-A	view
P43304	Glycerol-3-phosphate dehydrogenase, mitochondrial	GPD2	view
P47712	Cytosolic phospholipase A2	CPLA2 PLA2G4 PLA2G4A	view
Q13018	Secretory phospholipase A2 receptor	CLEC13C PLA2R1	view
Q13393	Phospholipase D1	PLD1	view
Q643R3	Lysophospholipid acyltransferase LPCAT4	AGPAT7 AYTL3 LPCAT4 LPEAT2	view
Q6XZB0	Lipase member I	LIPI LPDL PRED5	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_001087	Q13018	Secretory phospholipase A2 receptor	view

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