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Attachment of GPI anchor to uPAR

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-162791

PubChem

R-HSA-162791

Description

The mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves the uPAR polypeptide after residue 305, releasing the carboxyterminal peptide of uPAR and replacing it with an acylated GPI moiety. In a second step, the GPI moiety is deacylated, yielding a uPAR-GPI conjugate that can be efficiently transported to the Golgi apparatus.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43292	GPI-anchor transamidase component GPAA1	GAA1 GPAA1	view
Q03405	Urokinase plasminogen activator surface receptor	MO3 PLAUR UPAR	view
Q75T13	GPI inositol-deacylase	PGAP1 UNQ3024/PRO9822	view
Q92643	GPI-anchor transamidase	GPI8 PIGK	view
Q969N2	GPI-anchor transamidase component PIGT	CGI-06 PIGT PSEC0163 UNQ716/PRO1379	view
Q96S52	GPI-anchor transamidase component PIGS	PIGS UNQ1873/PRO4316	view
Q9H490	GPI-anchor transamidase component PIGU	CDC91L1 PIGU PSEC0205 UNQ3055/PRO9875	view

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