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AMPK inhibits chREBP transcriptional activation activity

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-163680

PubChem

R-HSA-163680

Description

AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	AMPK AMPK2 PRKAA2	view
Q15848	Adiponectin	ACDC ACRP30 ADIPOQ APM1 GBP28	view
Q9NP71	Carbohydrate-responsive element-binding protein	BHLHD14 MIO MLXIPL WBSCR14	view
Q9UGJ0	5'-AMP-activated protein kinase subunit gamma-2	PRKAG2	view

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