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2-LTR circle formation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-164843

PubChem

R-HSA-164843

Description

The formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this is provided by the observation that cells mutant in these functions do not support detectable formation of 2-LTR circles, though integration and formation of 1-LTR circles are mostly normal. The reaction takes place in the nucleus, and formation of 2-LTR circles has been used as a surrogate assay for nuclear transport. It has also been suggested that the NHEJ system affects the toxicity of retroviral infection.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75475	PC4 and SFRS1-interacting protein	DFS70 LEDGF PSIP1 PSIP2	view
P12956	DNA repair protein Ku70	G22P1 XRCC6	view
P13010	DNA repair protein Ku80	G22P2 XRCC5	view

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