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Nef mediated downregulation of MHC class I complex cell surface expression

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-164940

PubChem

R-HSA-164940

Description

Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04439	HLA class I histocompatibility antigen, A alpha chain	HLA-A HLAA	view
P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	B2M CDABP0092 HDCMA22P	view
Q6VY07	Phosphofurin acidic cluster sorting protein 1	KIAA1175 PACS1	view
Q9BXS5	AP-1 complex subunit mu-1	AP1M1 CLTNM	view
Q9Y6Q5	AP-1 complex subunit mu-2	AP1M2	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005335	P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	view

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