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The activation of arylsulfatases

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1663150

PubChem

R-HSA-1663150

Description

Sulfatase activity requires a unique posttranslational modification (PTM) of a catalytic cysteine residue into a formylglycine. This modification is impaired in patients with multiple sulfatase deficiency (MSD) due to defects in the SUMF1 (sulfatase-modifying factor 1) gene responsible for this PTM. SUMF2 can inhibit the activity of SUMF1 thereby providing a mechanism for the regulation of sulfatase activation (Ghosh 2007, Diez-Roux & Ballabio 2005).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 12 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08842	Steryl-sulfatase	ARSC1 STS	view
P15289	Arylsulfatase A	ARSA	view
P15848	Arylsulfatase B	ARSB	view
P51689	Arylsulfatase D	ARSD	view
P51690	Arylsulfatase L	ARSE ARSL	view
P54793	Arylsulfatase F	ARSF	view
Q5FYB0	Arylsulfatase J	ARSJ UNQ372/PRO708	view
Q5FYB1	Arylsulfatase I	ARSI	view
Q6UWY0	Arylsulfatase K	ARSK TSULF UNQ630/PRO1246	view
Q8NBJ7	Inactive C-alpha-formylglycine-generating enzyme 2	PSEC0171 SUMF2 UNQ1968/PRO4500	view

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