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PLC-gamma1 signalling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-167021

PubChem

R-HSA-167021

Description

The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01138	Beta-nerve growth factor	NGF NGFB	view
P04629	High affinity nerve growth factor receptor	MTC NTRK1 TRK TRKA	view
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1 PLCG1	view

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