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NGF processing

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-167060

PubChem

R-HSA-167060

Description

All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01138	Beta-nerve growth factor	NGF NGFB	view
P09958	Furin	FUR FURIN PACE PCSK3	view
P29122	Proprotein convertase subtilisin/kexin type 6	PACE4 PCSK6	view
Q92824	Proprotein convertase subtilisin/kexin type 5	PC5 PC6 PCSK5	view

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