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Inhibition of Host mRNA Processing and RNA Silencing

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-168315

PubChem

R-HSA-168315

Description

The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95639	Cleavage and polyadenylation specificity factor subunit 4	CPSF30 CPSF4 NAR NEB1	view
Q86U42	Polyadenylate-binding protein 2	PAB2 PABP2 PABPN1	view

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