GlyCosmos Portal

Submissions

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-174178

PubChem

R-HSA-174178

Description

From late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Geminin (see Castro et al., 2005). Rape et al. have recently demonstrated that the order in which APC/C targeted proteins are degraded is determined by the processivity of multiubiquitination of these substrates. Processive substrates acquire a polyubiquitin chain upon binding to the APC/C once and are degraded. Distributive substrates bind, dissociate and reassociate with the APC/C multiple times before acquiring an ubiquitin chain of sufficient length to insure degradation. In addition, distributive substrates that dissociate from the APC/C with short ubiquitin chains are targeted for deubiquitination (Rape et al., 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 32 in total

1

2

3

4

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
P06400	Retinoblastoma-associated protein	RB1	view
P17980	26S proteasome regulatory subunit 6A	PSMC3 TBP1	view
P20618	Proteasome subunit beta type-1	PSC5 PSMB1	view
P25786	Proteasome subunit alpha type-1	HC2 NU PROS30 PSC2 PSMA1	view
P25788	Proteasome subunit alpha type-3	HC8 PSC8 PSMA3	view
P25789	Proteasome subunit alpha type-4	HC9 PSC9 PSMA4	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.