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Telomere C-strand synthesis initiation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-174430

PubChem

R-HSA-174430

Description

DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. There have been reports that TRF1 inhibits this activity at telomeres, though the mechanism and physiological relevance of this inhibition remain to be elucidated.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P09884	DNA polymerase alpha catalytic subunit	POLA POLA1	view
Q14181	DNA polymerase alpha subunit B	POLA2	view
Q15554	Telomeric repeat-binding factor 2	TERF2 TRBF2 TRF2	view
Q96AP0	Adrenocortical dysplasia protein homolog	ACD PIP1 PTOP TINT1 TPP1	view
Q9NYB0	Telomeric repeat-binding factor 2-interacting protein 1	DRIP5 PP8000 RAP1 TERF2IP	view

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