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Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-176407

PubChem

R-HSA-176407

Description

The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1 (reviewed in Castro et al, 2005).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P30260	Cell division cycle protein 27 homolog	ANAPC3 CDC27 D0S1430E D17S978E	view
Q13042	Cell division cycle protein 16 homolog	ANAPC6 CDC16	view
Q9H1A4	Anaphase-promoting complex subunit 1	ANAPC1 TSG24	view
Q9UJX2	Cell division cycle protein 23 homolog	ANAPC8 CDC23	view
Q9UJX3	Anaphase-promoting complex subunit 7	ANAPC7 APC7	view
Q9UM11	Fizzy-related protein homolog	CDH1 FYR FZR FZR1 KIAA1242	view

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