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Regulation of APC/C activators between G1/S and early anaphase

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-176408

PubChem

R-HSA-176408

Description

The APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zachariae and Nasmyth, 1999). Cdc20, whose protein levels increase as cells enter into mitosis and decrease upon mitotic exit, only associates with the APC/C during M phase. Cdh1 associates with the APC/C in G1. This interaction is inhibited at other times by Cdk1 phosphorylation.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P30260	Cell division cycle protein 27 homolog	ANAPC3 CDC27 D0S1430E D17S978E	view
Q13042	Cell division cycle protein 16 homolog	ANAPC6 CDC16	view
Q9H1A4	Anaphase-promoting complex subunit 1	ANAPC1 TSG24	view
Q9UJX2	Cell division cycle protein 23 homolog	ANAPC8 CDC23	view
Q9UJX3	Anaphase-promoting complex subunit 7	ANAPC7 APC7	view
Q9UKT4	F-box only protein 5	EMI1 FBX5 FBXO5	view
Q9UM11	Fizzy-related protein homolog	CDH1 FYR FZR FZR1 KIAA1242	view

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