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RIP-mediated NFkB activation via ZBP1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1810476

PubChem

R-HSA-1810476

Description

Overexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implicated in ZBP1-induced NFkB activation (Rebsamen M et al 2009; Kaiser WJ et al 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB IKKB	view
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	CHUK IKKA TCF16	view
O15455	Toll-like receptor 3	TLR3	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
Q00653	Nuclear factor NF-kappa-B p100 subunit	LYT10 NFKB2	view
Q04206	Transcription factor p65	NFKB3 RELA	view
Q08211	ATP-dependent RNA helicase A	DDX9 DHX9 LKP NDH2	view
Q13546	Receptor-interacting serine/threonine-protein kinase 1	RIP RIP1 RIPK1	view
Q99836	Myeloid differentiation primary response protein MyD88	MYD88	view
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	RIP3 RIPK3	view

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