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snRNP Assembly

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-191859

PubChem

R-HSA-191859

Description

Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA differs from the other snRNAs; it binds seven Sm-like proteins and its assembly does not involve a cytoplasmic phase. The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. The assembly of the snRNA:Sm-core is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and binds the RNA-binding Sm proteins.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 35 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8CG34	Nuclear envelope pore membrane protein POM 121C	POM121C	view
O14744	Protein arginine N-methyltransferase 5	HRMT1L5 IBP72 JBP1 PRMT5 SKB1	view
O15504	Nucleoporin NUP42	CG1 NUP42 NUPL2	view
O75694	Nuclear pore complex protein Nup155	KIAA0791 NUP155	view
O95149	Snurportin-1	RNUT1 SNUPN SPN1	view
P12270	Nucleoprotein TPR	TPR	view
P14678	Small nuclear ribonucleoprotein-associated proteins B and B'	COD SNRPB SNRPB1	view
P35658	Nuclear pore complex protein Nup214	CAIN CAN KIAA0023 NUP214	view
P37198	Nuclear pore glycoprotein p62	NUP62	view
P49790	Nuclear pore complex protein Nup153	NUP153	view

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