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Synthesis of bile acids and bile salts

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-192105

PubChem

R-HSA-192105

Description

In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways occur in extrahepatic tissues, generating intermediates that are transported to the liver and converted to bile salts via the 7alpha-hydroxycholesterol pathway. These extrahepatic pathways contribute little to the total synthesis of bile salts, but are thought to play important roles in cholesterol homeostasis (Javitt 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95992	Cholesterol 25-hydroxylase	CH25H	view
P22059	Oxysterol-binding protein 1	OSBP OSBP1	view
Q15596	Nuclear receptor coactivator 2	BHLHE75 NCOA2 SRC2 TIF2	view
Q15788	Nuclear receptor coactivator 1	BHLHE74 NCOA1 SRC1	view
Q9BXW6	Oxysterol-binding protein-related protein 1	ORP1 OSBP8 OSBPL1 OSBPL1A OSBPL1B	view
Q9BZF2	Oxysterol-binding protein-related protein 7	ORP7 OSBPL7	view

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