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Neuropilin interactions with VEGF and VEGFR

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-194306

PubChem

R-HSA-194306

Description

The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neuropilin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14786	Neuropilin-1	NRP NRP1 VEGF165R	view
O60462	Neuropilin-2	NRP2 VEGF165R2	view
P17948	Vascular endothelial growth factor receptor 1	FLT FLT1 FRT VEGFR1	view
P35968	Vascular endothelial growth factor receptor 2	FLK1 KDR VEGFR2	view

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