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Glycosaminoglycan-protein linkage region biosynthesis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1971475

PubChem

R-HSA-1971475

Description

The biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The first step is the addition of xylose to the hydroxy group of specific serine residues on the core protein. Subsequent additions of two galactoses and a glucuronide moiety completes the linker sequence. From here, the next hexosamine addition is critical as it determines which GAG is formed (Lamberg & Stoolmiller 1974, Pavao et al. 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 29 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00468	Agrin	AGRIN AGRN	view
O14594	Neurocan core protein	CSPG3 NCAN NEUR	view
O75056	Syndecan-3	KIAA0468 SDC3	view
O75063	Glycosaminoglycan xylosylkinase	FAM20B KIAA0475	view
O75487	Glypican-4	GPC4 UNQ474/PRO937	view
O94766	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	B3GAT3 hCG_16017	view
O95196	Chondroitin sulfate proteoglycan 5	CALEB CSPG5 NGC	view
P07585	Decorin	DCN DKFZp686J19238 SLRR1B hCG_24110	view
P13611	Versican core protein	CSPG2 VCAN	view
P18827	Syndecan-1	SDC SDC1	view

Displaying **all 5** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000109	Q96GW7	Brevican core protein	view
GL_000807	O14594	Neurocan core protein	view
GL_001169	P13611	Versican core protein	view
GL_005327	O00468	Agrin	view
GL_005334	P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	view

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