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CREB phosphorylation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-199920

PubChem

R-HSA-199920

Description

Nerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial event in neurotrophin signalling, being mediated by ERK/RSK, ERK/MSK1 and p38/MAPKAPK2 pathways. Several kinases, such as MSK1, RSK1/2/3 (MAPKAPK1A/B/C), and MAPKAPK2, are able to directly phosphorylate CREB at S133. MSK1 is also able to activate ATF (Cyclic-AMP-dependent transcription factor). However, the NGF-induced CREB phosphorylation appears to correlate better with activation of MSK1 rather than RSK1/2/3, or MAPKAPK2. In retrograde signalling, activation of CREB occurs within 20 minutes after neurotrophin stimulation of distal axons.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75582	Ribosomal protein S6 kinase alpha-5	MSK1 RPS6KA5	view
P18846	Cyclic AMP-dependent transcription factor ATF-1	ATF1	view
P51812	Ribosomal protein S6 kinase alpha-3	ISPK1 MAPKAPK1B RPS6KA3 RSK2	view
Q15418	Ribosomal protein S6 kinase alpha-1	MAPKAPK1A RPS6KA1 RSK1	view

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