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Regulation of gene expression in beta cells

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-210745

PubChem

R-HSA-210745

Description

Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expression in turn is controlled by the activities of MAFA, FOXA2, and PAX6, and negatively regulated via AKT (Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P11168	Solute carrier family 2, facilitated glucose transporter member 2	GLUT2 SLC2A2	view
P20823	Hepatocyte nuclear factor 1-alpha	HNF1A TCF1	view
Q12778	Forkhead box protein O1	FKHR FOXO1 FOXO1A	view
Q8NHW3	Transcription factor MafA	MAFA	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002596	P35557	Hexokinase-4	view

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