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PECAM1 interactions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-210990

PubChem

R-HSA-210990

Description

PECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activation and angiogenesis. It has six Ig homology domains within its extracellularly and an ITIM motif within its cytoplasmic region. PECAM-1 mediates cellular interactions by both homophilic and heterophilic interactions. The cytoplasmic domain of PECAM-1 contains tyrosine residues which serves as docking sites for recruitment of cytosolic signaling molecules. Under conditions of platelet activation, PECAM-1 is phosphorylated by Src kinase members. The tyrosine residues 663 and 686 are required for recruitment of the SH2 domain containing PTPs.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P05106	Integrin beta-3	GP3A ITGB3	view
P06756	Integrin alpha-V	ITGAV MSK8 VNRA VTNR	view
P07947	Tyrosine-protein kinase Yes	YES YES1	view
P16284	Platelet endothelial cell adhesion molecule	PECAM1	view
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1 PLCG1	view
P29350	Tyrosine-protein phosphatase non-receptor type 6	HCP PTP1C PTPN6	view
Q06124	Tyrosine-protein phosphatase non-receptor type 11	PTP2C PTPN11 SHPTP2	view
Q92835	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	INPP5D SHIP SHIP1	view

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