GlyCosmos Portal

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Molecules associated with elastic fibres

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2129379

PubChem

R-HSA-2129379

Description

Proteins found associated with microfibrils include vitronectin (Dahlback et al. 1990), latent transforming growth factor beta-binding proteins (Kielty et al. 2002, Munger & Sheppard 2011), emilin (Bressan et al. 1993, Mongiat et al. 2000), members of the microfibrillar-associated proteins (MFAPs, Gibson et al.1996), and fibulins (Roark et al. 1995, Yanagisawa et al. 2002). The significance of these interactions is not well understood but may help mediate elastin-fibrillin interactions during elastic fibre assembly.

Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 37 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95393	Bone morphogenetic protein 10	BMP10	view
O95967	EGF-containing fibulin-like extracellular matrix protein 2	EFEMP2 FBLN4 UNQ200/PRO226	view
P01137	Transforming growth factor beta-1 proprotein	TGFB TGFB1	view
P02751	Fibronectin	FN FN1	view
P04004	Vitronectin	VTN	view
P05106	Integrin beta-3	GP3A ITGB3	view
P05556	Integrin beta-1	FNRB ITGB1 MDF2 MSK12	view
P06756	Integrin alpha-V	ITGAV MSK8 VNRA VTNR	view
P10600	Transforming growth factor beta-3 proprotein	TGFB3	view
P12643	Bone morphogenetic protein 2	BMP2 BMP2A	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002853	P04004	Vitronectin	view

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