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Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2142670

PubChem

R-HSA-2142670

Description

The epoxidation of arachidonate by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoates (EETs). Each double bond has been shown to be susceptible to oxidation, resulting in 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. The majority of the EET biological activities are diminished by the hydrolysis to the corresponding dihydroxyeicosatrienoates (DHET) (Capdevila et al. 2000, Buczynski et al. 2009, Vance & Vance 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04798	Cytochrome P450 1A1	CYP1A1	view
P05177	Cytochrome P450 1A2	CYP1A2	view

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