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Synthesis of Leukotrienes (LT) and Eoxins (EX)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2142691

PubChem

R-HSA-2142691

Description

Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and activation of leukocytes. LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. LTs are derived from arachidonate through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P09960	Leukotriene A-4 hydrolase	LTA4 LTA4H	view
P16444	Dipeptidase 1	DPEP1 MDP RDP	view
P19440	Glutathione hydrolase 1 proenzyme	GGT GGT1	view
P20292	Arachidonate 5-lipoxygenase-activating protein	ALOX5AP FLAP	view
P33527	Multidrug resistance-associated protein 1	ABCC1 MRP MRP1	view
P36269	Glutathione hydrolase 5 proenzyme	GGT5 GGTLA1	view
Q9H4A9	Dipeptidase 2	DPEP2 UNQ284/PRO323	view

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