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Condensation of Prophase Chromosomes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2299718

PubChem

R-HSA-2299718

Description

In mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.

The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associating with chromatin (Liu et al. 2010). Binding of the condensin II complex to chromatin is partially controlled by the presence of RB1 (Longworth et al. 2008).

Two mechanisms contribute to the accumulation of H4K20me1 at mitotic entry. First, the activity of SETD8 histone methyltransferase peaks at G2/M transition (Nishioka et al. 2002, Rice et al. 2002, Wu et al. 2010). Second, the complex of CDK1 and cyclin B1 (CDK1:CCNB1) phosphorylates PHF8 histone demethylase at the start of mitosis, removing it from chromatin (Liu et al. 2010).

Condensin II complex needs to be phosphorylated by the CDK1:CCNB1 complex, and then phosphorylated by PLK1, in order to efficiently condense prophase chromosomes (Abe et al. 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 29 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
O95347	Structural maintenance of chromosomes protein 2	CAPE PRO0324 SMC2 SMC2L1	view
P04908	Histone H2A type 1-B/E	H2AC4; H2AC8 H2AFA H2AFM HIST1H2AB HIST1H2AE	view
P06400	Retinoblastoma-associated protein	RB1	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P16104	Histone H2AX	H2AFX H2AX	view
P23527	Histone H2B type 1-O	H2BC17 H2BFH H2BFN HIST1H2BO	view
P33778	Histone H2B type 1-B	H2BC3 H2BFF HIST1H2BB	view
P42695	Condensin-2 complex subunit D3	CAPD3 KIAA0056 NCAPD3	view
P53350	Serine/threonine-protein kinase PLK1	PLK PLK1	view

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