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DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-3134963

PubChem

R-HSA-3134963

Description

DHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of proteins that are implicated in RNA metabolism. Members of this family, RIG-1 and MDA5, have been shown to sense a non-self RNA leading to type I IFN production. RNA helicases DHX36 and DHX9 were found to trigger host responses to non-self DNA in MyD88-dependent manner. DHX36 sensed CpG class A, while DHX9 sensed CpG class B. Both DHX36 and DHX9 were critical for antiviral immune responses in viral DNA-stimulated human plasmacytoid dendritic cells (pDC) (Kim T et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
Q00653	Nuclear factor NF-kappa-B p100 subunit	LYT10 NFKB2	view
Q04206	Transcription factor p65	NFKB3 RELA	view
Q08211	ATP-dependent RNA helicase A	DDX9 DHX9 LKP NDH2	view
Q92985	Interferon regulatory factor 7	IRF7	view
Q99836	Myeloid differentiation primary response protein MyD88	MYD88	view
Q9H2U1	ATP-dependent DNA/RNA helicase DHX36	DDX36 DHX36 KIAA1488 MLEL1 RHAU	view

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