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Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-381771

PubChem

R-HSA-381771

Description

In L cells of the intestine the transcription factors TCF-4 (TCF7L2) and Beta-catenin form a heterodimer and bind the G2 enhancer of the Proglucagon gene GCG,activating its transcription to yield Proglucagon mRNA and, following translation, Proglucagon protein. The prohormone convertase PC1 present in the secretory granules of L cells cleaves Proglucagon at two sites to yield mostly Glucagon-like Peptide-1 (7-36) with a small amount of Glucagon-like Peptide-1 (7-37). Glucagon-like Peptide-1 (7-36 and 7-37) (GLP-1) is secreted into the bloodstream in response to glucose, fatty acids, insulin, leptin, gastrin-releasing peptide, cholinergic transmitters, beta-adrenergic transmitters, and peptidergic transmitters. The half-life of GLP-1 in the bloodstream is determined by Dipeptidyl Peptidase IV, which cleaves 2 amino acids at the amino terminus of GLP-1, rendering it biologically inactive.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8MTJ3	Guanine nucleotide-binding protein G(t) subunit alpha-3	GNAT3	view
O14842	Free fatty acid receptor 1	FFAR1 GPR40	view
P07492	Gastrin-releasing peptide	GRP	view
P27487	Dipeptidyl peptidase 4	ADCP2 CD26 DPP4	view
P29120	Neuroendocrine convertase 1	NEC1 PCSK1	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P61009	Signal peptidase complex subunit 3	SPC22 SPCS3 UNQ1841/PRO3567	view
P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNB1	view
Q15005	Signal peptidase complex subunit 2	KIAA0102 SPC25 SPCS2	view
Q5NUL3	Free fatty acid receptor 4	FFAR4 GPR120 GPR129 O3FAR1 PGR4	view

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