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ABC-family protein mediated transport

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-382556

PubChem

R-HSA-382556

Description

The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 47 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O15438	ATP-binding cassette sub-family C member 3	ABCC3 CMOAT2 MLP2 MRP3	view
O15439	ATP-binding cassette sub-family C member 4	ABCC4 MOATB MRP4	view
O15440	ATP-binding cassette sub-family C member 5	ABCC5 MRP5	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O60706	ATP-binding cassette sub-family C member 9	ABCC9 SUR2	view
O75477	Erlin-1	C10orf69 ERLIN1 KE04 KEO4 SPFH1	view
O94905	Erlin-2	C8orf2 ERLIN2 SPFH2 UNQ2441/PRO5003/PRO9924	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000990	Q13438	Protein OS-9	view
GL_005506	Q9UBV2	Protein sel-1 homolog 1	view

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