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Alpha-oxidation of phytanate

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-389599

PubChem

R-HSA-389599

Description

Phytanic acid arises through ruminant metabolism of chlorophyll and enters the human diet as a constituent of dairy products (Baxter 1968). It can act as an agonist for PPAR and other nuclear hormone receptors, but its normal role in human physiology, if any, is unclear. It is catabolized via a five-step alpha-oxidation reaction sequence that yields pristanoyl-CoA, which is turn is a substrate for beta-oxidation. These reactions take place in the peroxisomal matrix and their failure is associated with Refsum disease (Wanders et al. 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14975	Long-chain fatty acid transport protein 2	ACSVL1 FACVL1 FATP2 SLC27A2 VLACS	view
Q9BY49	Peroxisomal trans-2-enoyl-CoA reductase	PECR PRO1004 SDR29C1	view
Q9UJ83	2-hydroxyacyl-CoA lyase 1	HACL1 HPCL HPCL2 HSPC279 PHYH2	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005069	O14832	Phytanoyl-CoA dioxygenase, peroxisomal	view

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