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Glyoxylate metabolism and glycine degradation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-389661

PubChem

R-HSA-389661

Description

Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate (Danpure 2005). The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q86XE5	4-hydroxy-2-oxoglutarate aldolase, mitochondrial	C10orf65 DHDPSL HOGA1	view
Q9UBQ7	Glyoxylate reductase/hydroxypyruvate reductase	GLXR GRHPR MSTP035	view
Q9UF12	Hydroxyproline dehydrogenase	HSPOX1 HYPDH PRODH2	view

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