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Adrenaline signalling through Alpha-2 adrenergic receptor

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-392023

PubChem

R-HSA-392023

Description

Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, induction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08913	Alpha-2A adrenergic receptor	ADRA2A ADRA2R ADRAR	view
P18825	Alpha-2C adrenergic receptor	ADRA2C ADRA2L2 ADRA2RL2	view

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