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ADP signalling through P2Y purinoceptor 12

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-392170

PubChem

R-HSA-392170

Description

Co-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible platelet aggregation. P2Y12 is Gi coupled, inhibiting adenylate cyclase, leading to decreased cAMP, a consequent decrease in cAMP-dependent protein kinase activity which increases cytoplasmic [Ca2+], necessary for activation (Woulfe et al. 2001).
In activated platelets, P2Y12 signaling is required for the amplification of aggregation induced by all platelet agonists including collagen, thrombin, thromboxane, adrenaline and serotonin. P2Y12 activation causes potentiation of thromboxane generation, secretion leading to irreversible platelet aggregation and thrombus stabilization.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8MTJ3	Guanine nucleotide-binding protein G(t) subunit alpha-3	GNAT3	view
P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	GNAI2 GNAI2B	view
P08754	Guanine nucleotide-binding protein G(i) subunit alpha-3	GNAI3	view
P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNB1	view
P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	GNAI1	view
Q9H244	P2Y purinoceptor 12	HORK3 P2RY12	view
Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	GNB4	view

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