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Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-400511

PubChem

R-HSA-400511

Description

In K cells of the intestine the transcription factors PAX6 and PDX-1 activate transcription of the gene encoding Glucose-dependent Insulinotropic Polypeptide (GIP, first called Gastric Inhibitory Peptide). ProGIP is cleaved in secretory granules by Prohormone Convertase 1 (PC1) at 2 sites to yield mature GIP. In response to fat the GIP is secreted into the bloodstream. The half-life of GIP in the bloodstream is determined by Dipeptidyl Peptidase IV, which cleaves 2 amino acids at the amino terminus of GIP, rendering it biologically inactive.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14842	Free fatty acid receptor 1	FFAR1 GPR40	view
P27487	Dipeptidyl peptidase 4	ADCP2 CD26 DPP4	view
P29120	Neuroendocrine convertase 1	NEC1 PCSK1	view
P43694	Transcription factor GATA-4	GATA4	view
P61009	Signal peptidase complex subunit 3	SPC22 SPCS3 UNQ1841/PRO3567	view
Q15005	Signal peptidase complex subunit 2	KIAA0102 SPC25 SPCS2	view

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