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Platelet homeostasis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-418346

PubChem

R-HSA-418346

Description

Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelial dilating agents: adenosine, NO and prostacyclin; and by the direct action of ADP, serotonin and thromboxane on vascular smooth muscle cells to elicit their contraction (Becker et al. 2000). Cyclooxygenase-2 (COX-2) and endothelial nitric oxide synthase (eNOS) are primarily expressed in endothelial cells. Both are important regulators of vascular function. Under normal conditions, laminar flow induces vascular endothelial COX-2 expression and synthesis of Prostacyclin (PGI2) which in turn stimulates endothelial Nitric Oxide Synthase (eNOS) activity. PGI2 and NO both oppose platelet activation and aggregation, as does the CD39 ecto-ADPase, which decreases platelet activation and recruitment by metabolizing platelet-released ADP.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15547	P2X purinoceptor 6	P2RX6 P2RXL1 P2X6	view
P51575	P2X purinoceptor 1	P2RX1 P2X1	view
P56373	P2X purinoceptor 3	P2RX3	view
Q93086	P2X purinoceptor 5	P2RX5 P2X5 P2X5FL	view
Q99571	P2X purinoceptor 4	P2RX4	view
Q99572	P2X purinoceptor 7	P2RX7	view
Q9UBL9	P2X purinoceptor 2	P2RX2 P2X2	view

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