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Small interfering RNA (siRNA) biogenesis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-426486

PubChem

R-HSA-426486

Description

Small interfering RNAs (siRNAs) are 21-25 nucleotide single-stranded RNAs produced by cleavage of longer double-stranded RNAs by the enzyme DICER1 within the RISC loading complex containing DICER1, an Argonaute protein, and either TARBP2 or PRKRA (PACT). Typically the long double-stranded substrates originate from viruses or repetitive elements in the genome and the two strands of the substrate are exactly complementary.
After cleavage by DICER1 the 21-25 nucleotide double-stranded product is loaded into an Argonuate protein (humans contain 4 Argonautes) and rendered single-stranded by a mechanism that is not well characterized.
siRNA-loaded AGO2 is predominantly located at the cytosolic face of the rough endoplasmic reticulum and has also been observed in the nucleus.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	HSD-14 HSD14 PACT PRKRA RAX	view
Q15631	Translin	TSN	view
Q15633	RISC-loading complex subunit TARBP2	TARBP2 TRBP	view
Q99598	Translin-associated protein X	TRAX TSNAX	view
Q9H9G7	Protein argonaute-3	AGO3 EIF2C3	view
Q9UKV8	Protein argonaute-2	AGO2 EIF2C2	view
Q9UL18	Protein argonaute-1	AGO1 EIF2C1	view
Q9UPY3	Endoribonuclease Dicer	DICER DICER1 HERNA KIAA0928	view

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