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Post-transcriptional silencing by small RNAs

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-426496

PubChem

R-HSA-426496

Description

Small RNAs act with components of the RNA-induced silencing complex (RISC) to post-transcriptionally repress expression of mRNAs (reviewed in Nowotny and Yang 2009, Chua et al. 2009). Two mechanisms exist: 1) cleavage of target RNAs by complexes containing Argonaute2 (AGO2, EIF2C2) and a guide RNA that exactly matches the target mRNA and 2) inhibition of translation of target RNAs by complexes containing AGO2 and an inexactly matching guide RNA or by complexes containing a nonendonucleolytic Argonaute (AGO1 (EIF2C1), AGO3 (EIF2C3), or AGO4 (EIF2C4)) and a guide RNA of exact or inexact match. Small interfering RNAs (siRNAs) and microRNAs (miRNAs) can serve as guide RNAs in both types of mechanism.
RNAi also appears to direct chromatin modifications that cause transcriptional gene silencing (reviewed in Verdel et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	CAGH26 KIAA1460 TNRC6 TNRC6A	view
Q9H9G7	Protein argonaute-3	AGO3 EIF2C3	view
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	KIAA1582 TNRC6C	view
Q9UKV8	Protein argonaute-2	AGO2 EIF2C2	view
Q9UL18	Protein argonaute-1	AGO1 EIF2C1	view
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	KIAA1093 TNRC6B	view

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