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Inositol transporters

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-429593

PubChem

R-HSA-429593

Description

Myo-Inositol is a neutral cyclic polyol, abundant in mammalian tissues. It plays important roles; it is a precursor to phosphatidylinositols (PtdIns) and to the inositol phosphates (IP), which serve as second messengers and as key regulators of many cell functions. It can also serve as a compatible osmolyte during volume regulation in many tissues where cells are exposed to hyperosmotic conditions. Three members of the glucose transporter families are inositol transporters. Two (SMIT1 and SMIT2) couple myo-inositol transport with two Na+ ions. Unlike SMIT1, SMIT2 also transports D-chiro_inositol. The third transporter (HMIT), couples myo-inositol transport with a proton.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P53794	Sodium/myo-inositol cotransporter	SLC5A3	view
Q8WWX8	Sodium/myo-inositol cotransporter 2	KST1 SLC5A11 SLGTX SMIT2	view
Q96QE2	Proton myo-inositol cotransporter	SLC2A13	view

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