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Vasopressin regulates renal water homeostasis via Aquaporins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-432040

PubChem

R-HSA-432040

Description

In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 22 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43306	Adenylate cyclase type 6	ADCY6 KIAA0422	view
O60266	Adenylate cyclase type 3	ADCY3 KIAA0511	view
O60503	Adenylate cyclase type 9	ADCY9 KIAA0520	view
O95622	Adenylate cyclase type 5	ADCY5	view
P01185	Vasopressin-neurophysin 2-copeptin	ARVP AVP VP	view
P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	PKR1 PRKAR1 PRKAR1A TSE1	view
P22694	cAMP-dependent protein kinase catalytic subunit beta	PRKACB	view
P29972	Aquaporin-1	AQP1 CHIP28	view
P30518	Vasopressin V2 receptor	ADHR AVPR2 DIR DIR3 V2R	view
P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	PRKAR1B	view

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