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CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-442742

PubChem

R-HSA-442742

Description

Ca2+ influx through the NMDA receptor activates RAS guanyl nucleotide exchange factor RasGRF, which promotes formation of active RAS:GTP complexes (Anborgh et al. 1999, Krapivinsky et al. 2003). CaMKII, also activated by NMDA receptor-mediated Ca2+ influx, can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012). ERKs (MAPK1 and MAPK3), activated downstream of RAS signaling, phosphorylate ribosomal protein S6 kinases (RSKs), initiating activation of RSKs (reviewed by Anjum and Blenis 2012). Activated RSKs phosphorylate the transcription factor CREB1 at serine residue S133, thus stimulating CREB1-mediated transcription (De Cesare et al. 1998, Harum et al. 2001, Schinelli et al. 2001, Song et al. 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P51812	Ribosomal protein S6 kinase alpha-3	ISPK1 MAPKAPK1B RPS6KA3 RSK2	view
Q15418	Ribosomal protein S6 kinase alpha-1	MAPKAPK1A RPS6KA1 RSK1	view

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