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Free fatty acid receptors

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-444209

PubChem

R-HSA-444209

Description

Fatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120.

Free fatty acid receptor 1 (FFAR1/GPR40) is activated by both saturated and unsaturated medium to long-chain fatty acids while FFAR2 (GPR43) and FFAR3 (GPR41) are activated by short-chain fatty acids (carboxylates) with six or fewer carbon molecules. A fourth highly homologous receptor GPR42 is believed to be a pseudogene with intact open reading frame, but could be a functional gene in a significant fraction of the human population.

GPR120 is activated by long chain (C16-22) fatty acids.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00270	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor	GPR31	view
O14842	Free fatty acid receptor 1	FFAR1 GPR40	view
O14843	Free fatty acid receptor 3	FFAR3 GPR41	view
O15552	Free fatty acid receptor 2	FFA2 FFAR2 GPCR43 GPR43	view
Q5NUL3	Free fatty acid receptor 4	FFAR4 GPR120 GPR129 O3FAR1 PGR4	view

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