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HuR (ELAVL1) binds and stabilizes mRNA

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-450520

PubChem

R-HSA-450520

Description

HuR (ELAVL1) is a ubiquitous protein that binds AU-rich elements in mRNAs and acts to stabilize the mRNAs. HuR activity is controlled by phosphorylation, with PKC alpha and PCK delta enhancing the ability of HuR to bind and stabilize mRNAs. Binding of mRNAs occurs in the nucleus and HuR then interacts with the CRM1 export pathway to transfer the mRNA to the cytoplasm. The mechanism by which HuR shields the mRNA from degradation is unknown.
HuR also regulates translation of some mRNAs, in some cases repressing translation and in some cases enhancing translation of bound mRNAs by recruiting them to polysomes.
HuR binds and regulates mRNAs encoding Cyclooxygenase-2 (COX2, PTGS2), Cyclin A (CCNA, CCNA2), Cyclin D1 (CCND1), Cyclin B1 (CCNB1), CD83 antigen (CD83), and proto-oncogene c-Fos (FOS).
HuR is a member of a family of proteins that also contains HuD (ELAVL4), HuB (ELAVL2), and HuC (ELAVL3). HuB, HuC, and HuD are specifically expressed in neural tissue.
HuR participates in apoptosis. During lethal stress HuR becomes mostly cytoplasmic and is a target of Caspase-3 and Caspase-7. The cleavage products of HuR in turn promote apoptosis.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14980	Exportin-1	CRM1 XPO1	view
O75888	Tumor necrosis factor ligand superfamily member 13	APRIL TALL2 TNFSF13 UNQ383/PRO715 ZTNF2	view
P17252	Protein kinase C alpha type	PKCA PRKACA PRKCA	view
P35658	Nuclear pore complex protein Nup214	CAIN CAN KIAA0023 NUP214	view
Q01105	Protein SET	SET	view
Q15717	ELAV-like protein 1	ELAVL1 HUR	view

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